Nramp1 gene affects selective early steps in macrophage-mediated anti-cryptococcal defense
Identifieur interne : 002349 ( Main/Exploration ); précédent : 002348; suivant : 002350Nramp1 gene affects selective early steps in macrophage-mediated anti-cryptococcal defense
Auteurs : Elisabetta Blasi [Italie] ; Bruna Colombari [Italie] ; Anna Mucci [Italie] ; Andrea Cossarizza [Italie] ; Danuta Radzioch [Canada] ; Johan R. Boelaert [Belgique] ; Rachele Neglia [Italie]Source :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 2001-09-01.
English descriptors
Abstract
Abstract: Cryptococcus neoformans is an opportunistic fungus responsible for severe and often recurrent meningoencephalitis in immunodepressed patients. Initial evidence suggests that C. neoformans is a facultative intracellular pathogen; however, the strategies by which C. neoformans undergoes survival and eventually proliferation have not been elucidated. We investigated the role of Nramp1 gene in macrophage-mediated anti-cryptococcal defense. Using cell lines expressing the functional, mutated or knockout gene, it was established that Nramp1 (1) is not involved in the phagocytic event, (2) influences anti-cryptococcal activity in the early steps but not at later times, and (3) is unrelated to the biomolecular pathways through which C. neoformans impairs macrophage secretory response. Although the functional role of Nramp1 is still far from being elucidated, the present data add insight into its involvement in macrophage-mediated antimicrobial defense, particularly in the initial steps allowing C. neoformans growth inhibition.
Url:
DOI: 10.1007/s004300100066
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001174
- to stream Istex, to step Curation: 001174
- to stream Istex, to step Checkpoint: 001175
- to stream Main, to step Merge: 002374
- to stream Main, to step Curation: 002349
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nramp1 gene affects selective early steps in macrophage-mediated anti-cryptococcal defense</title><author><name sortKey="Blasi, Elisabetta" sort="Blasi, Elisabetta" uniqKey="Blasi E" first="Elisabetta" last="Blasi">Elisabetta Blasi</name></author><author><name sortKey="Colombari, Bruna" sort="Colombari, Bruna" uniqKey="Colombari B" first="Bruna" last="Colombari">Bruna Colombari</name></author><author><name sortKey="Mucci, Anna" sort="Mucci, Anna" uniqKey="Mucci A" first="Anna" last="Mucci">Anna Mucci</name></author><author><name sortKey="Cossarizza, Andrea" sort="Cossarizza, Andrea" uniqKey="Cossarizza A" first="Andrea" last="Cossarizza">Andrea Cossarizza</name></author><author><name sortKey="Radzioch, Danuta" sort="Radzioch, Danuta" uniqKey="Radzioch D" first="Danuta" last="Radzioch">Danuta Radzioch</name></author><author><name sortKey="Boelaert, Johan R" sort="Boelaert, Johan R" uniqKey="Boelaert J" first="Johan R." last="Boelaert">Johan R. Boelaert</name></author><author><name sortKey="Neglia, Rachele" sort="Neglia, Rachele" uniqKey="Neglia R" first="Rachele" last="Neglia">Rachele Neglia</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E56BE23B7DF039722B8CB5899D8C5A28CE7C3052</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1007/s004300100066</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-LWFMJKDN-9/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001174</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001174</idno><idno type="wicri:Area/Istex/Curation">001174</idno><idno type="wicri:Area/Istex/Checkpoint">001175</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001175</idno><idno type="wicri:doubleKey">0300-8584:2001:Blasi E:nramp:gene:affects</idno><idno type="wicri:Area/Main/Merge">002374</idno><idno type="wicri:Area/Main/Curation">002349</idno><idno type="wicri:Area/Main/Exploration">002349</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Nramp1 gene affects selective early steps in macrophage-mediated anti-cryptococcal defense</title><author><name sortKey="Blasi, Elisabetta" sort="Blasi, Elisabetta" uniqKey="Blasi E" first="Elisabetta" last="Blasi">Elisabetta Blasi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Igienistiche, Microbiologiche e Biostatistiche, Università di Modena e Reggio Emilia, Via Campi 287, 41100 Modena, Italy</wicri:regionArea><wicri:noRegion>Italy</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Italie</country></affiliation></author><author><name sortKey="Colombari, Bruna" sort="Colombari, Bruna" uniqKey="Colombari B" first="Bruna" last="Colombari">Bruna Colombari</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Igienistiche, Microbiologiche e Biostatistiche, Università di Modena e Reggio Emilia, Via Campi 287, 41100 Modena, Italy</wicri:regionArea><wicri:noRegion>Italy</wicri:noRegion></affiliation></author><author><name sortKey="Mucci, Anna" sort="Mucci, Anna" uniqKey="Mucci A" first="Anna" last="Mucci">Anna Mucci</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Igienistiche, Microbiologiche e Biostatistiche, Università di Modena e Reggio Emilia, Via Campi 287, 41100 Modena, Italy</wicri:regionArea><wicri:noRegion>Italy</wicri:noRegion></affiliation></author><author><name sortKey="Cossarizza, Andrea" sort="Cossarizza, Andrea" uniqKey="Cossarizza A" first="Andrea" last="Cossarizza">Andrea Cossarizza</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Biomediche, Università di Modena e Reggio Emilia, Modena, Italy</wicri:regionArea><wicri:noRegion>Italy</wicri:noRegion></affiliation></author><author><name sortKey="Radzioch, Danuta" sort="Radzioch, Danuta" uniqKey="Radzioch D" first="Danuta" last="Radzioch">Danuta Radzioch</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>McGill University Health Centre, Montreal, Quebec H3G 1A4, Canada</wicri:regionArea><wicri:noRegion>Canada</wicri:noRegion></affiliation></author><author><name sortKey="Boelaert, Johan R" sort="Boelaert, Johan R" uniqKey="Boelaert J" first="Johan R." last="Boelaert">Johan R. Boelaert</name><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>AZ St. Jan, Bruges, Belgium</wicri:regionArea><wicri:noRegion>Belgium</wicri:noRegion></affiliation></author><author><name sortKey="Neglia, Rachele" sort="Neglia, Rachele" uniqKey="Neglia R" first="Rachele" last="Neglia">Rachele Neglia</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Scienze Igienistiche, Microbiologiche e Biostatistiche, Università di Modena e Reggio Emilia, Via Campi 287, 41100 Modena, Italy</wicri:regionArea><wicri:noRegion>Italy</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Medical Microbiology and Immunology</title><title level="j" type="abbrev">Med Microbiol Immunol</title><idno type="ISSN">0300-8584</idno><idno type="eISSN">1432-1831</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2001-09-01">2001-09-01</date><biblScope unit="volume">189</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="209">209</biblScope><biblScope unit="page" to="216">216</biblScope></imprint><idno type="ISSN">0300-8584</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-8584</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cryptococcus neoformans Macrophages Nramp1 gene Anti-cryptococcal activity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Cryptococcus neoformans is an opportunistic fungus responsible for severe and often recurrent meningoencephalitis in immunodepressed patients. Initial evidence suggests that C. neoformans is a facultative intracellular pathogen; however, the strategies by which C. neoformans undergoes survival and eventually proliferation have not been elucidated. We investigated the role of Nramp1 gene in macrophage-mediated anti-cryptococcal defense. Using cell lines expressing the functional, mutated or knockout gene, it was established that Nramp1 (1) is not involved in the phagocytic event, (2) influences anti-cryptococcal activity in the early steps but not at later times, and (3) is unrelated to the biomolecular pathways through which C. neoformans impairs macrophage secretory response. Although the functional role of Nramp1 is still far from being elucidated, the present data add insight into its involvement in macrophage-mediated antimicrobial defense, particularly in the initial steps allowing C. neoformans growth inhibition.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Canada</li><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Blasi, Elisabetta" sort="Blasi, Elisabetta" uniqKey="Blasi E" first="Elisabetta" last="Blasi">Elisabetta Blasi</name></noRegion><name sortKey="Blasi, Elisabetta" sort="Blasi, Elisabetta" uniqKey="Blasi E" first="Elisabetta" last="Blasi">Elisabetta Blasi</name><name sortKey="Colombari, Bruna" sort="Colombari, Bruna" uniqKey="Colombari B" first="Bruna" last="Colombari">Bruna Colombari</name><name sortKey="Cossarizza, Andrea" sort="Cossarizza, Andrea" uniqKey="Cossarizza A" first="Andrea" last="Cossarizza">Andrea Cossarizza</name><name sortKey="Mucci, Anna" sort="Mucci, Anna" uniqKey="Mucci A" first="Anna" last="Mucci">Anna Mucci</name><name sortKey="Neglia, Rachele" sort="Neglia, Rachele" uniqKey="Neglia R" first="Rachele" last="Neglia">Rachele Neglia</name></country><country name="Canada"><noRegion><name sortKey="Radzioch, Danuta" sort="Radzioch, Danuta" uniqKey="Radzioch D" first="Danuta" last="Radzioch">Danuta Radzioch</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Boelaert, Johan R" sort="Boelaert, Johan R" uniqKey="Boelaert J" first="Johan R." last="Boelaert">Johan R. Boelaert</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002349 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002349 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E56BE23B7DF039722B8CB5899D8C5A28CE7C3052
|texte= Nramp1 gene affects selective early steps in macrophage-mediated anti-cryptococcal defense
}}
| This area was generated with Dilib version V0.6.33. |  |